{"id":311822,"date":"2023-04-04T17:57:39","date_gmt":"2023-04-04T20:57:39","guid":{"rendered":"http:\/\/ppgsc.uea.edu.br\/?p=311822"},"modified":"2024-09-05T16:33:59","modified_gmt":"2024-09-05T19:33:59","slug":"the-genetic-landscape-of-neuro-related-proteins-in","status":"publish","type":"post","link":"https:\/\/ppgsc.uea.edu.br\/index.php\/the-genetic-landscape-of-neuro-related-proteins-in\/","title":{"rendered":"The genetic landscape of neuro-related proteins in human plasma Nature Human Behaviour"},"content":{"rendered":"<p><img decoding=\"async\" class='wp-post-image' style='display: block;margin-left:auto;margin-right:auto;' src=\"https:\/\/ecosoberhouse.com\/wp-content\/uploads\/drinking-alcohol-during-pregnancy-500x333.webp\" width=\"304px\" alt=\"is alcoholism a hereditary disease\"\/><\/p>\n<p>Genetics plays a significant role in the size of the penis, but it is not the only factor. Nutritional deficiencies and  environmental toxins can impact the development of the penis inside and outside of the womb. Variations in the production of testosterone can also affect the development of the penis during puberty. \u201cGiven the significant risk of Alzheimer\u2019s disease and cardiovascular diseases \u2014 including coronary artery disease traits \u2014 globally, we were motivated to investigate potential genetic links between Alzheimer\u2019s disease and coronary artery disease traits,\u201d she added. Kirby is the lead author of a new study recently published in the International Journal of Molecular Science that has found a potential genetic link between Alzheimer\u2019s disease and several coronary artery disease-related disorders and lipids, such as cholesterol.<\/p>\n<p><img decoding=\"async\" class='aligncenter' style='display: block;margin-left:auto;margin-right:auto;' src=\"https:\/\/ecosoberhouse.com\/wp-content\/uploads\/image-9Odqbt5p3foxi1WS-1.webp\" width=\"304px\" alt=\"is alcoholism a hereditary disease\"\/><\/p>\n<h2>How much of addiction is genetic?<\/h2>\n<p>Your socioeconomic status can directly affect your mental and physical well-being. If you live in a situation of poverty, for example, or in an area with limited resources, you may be less likely to have access to quality foods, community services, or adequate healthcare. According to a review from 2016, genes that promote alcohol metabolism and the production of enzymes, <a href=\"https:\/\/ecosoberhouse.com\/\">https:\/\/ecosoberhouse.com\/<\/a> such as alcohol dehydrogenase and aldehyde dehydrogenase, can be protective against AUD. According to the DSM-5-TR, the more relatives you have living with AUD and the closer they are to you in relation, the higher your individual genetic risk becomes. Alcohol use disorder (AUD) can have a hereditary component, but not everyone living with AUD has a family history of AUD.<\/p>\n<ul>\n<li>&#8220;Moreover, individuals who learn that they are at higher risk through this tool may be motivated to adopt healthier lifestyles to help prevent the progression of disease,&#8221; she added.<\/li>\n<li>In vertebrates, neuropeptide Y (NPY) signaling plays a role in alcohol intake and dependence [61,62].<\/li>\n<li>However, minimizing environmental factors that increase the risk, decreasing the availability of alcohol, and maximizing protective factors can help reduce the likelihood of developing AUD.<\/li>\n<li>ALD is now the most common indication for liver transplant in those younger than 40 years of age, having increased fourfold between 2003 and 2018.<\/li>\n<li>&#8220;Genes explain approximately 50% of cases of alcohol use disorder,&#8221; says David A. Fiellin, MD, director of the Yale Program in Addiction Medicine.<\/li>\n<\/ul>\n<h2>Professional development<\/h2>\n<div style='text-align:center'><iframe width='567' height='319' src='https:\/\/www.youtube.com\/embed\/40nsYCuc3Ys' frameborder='0' alt='is alcoholism a hereditary disease' allowfullscreen><\/iframe><\/div>\n<p>In fact,&nbsp;new data suggests&nbsp;that there may be even more genetic variants involved in alcohol dependence. Invertebrate and vertebrate models show similar symptoms of alcohol intoxication, including loss of postural control, sedation, immobility and development of tolerance. After alcohol intoxication, mice and rats increase their alcohol consumption, develop tolerance and even alcohol dependence. In addition to rapid tolerance, flies develop chronic tolerance after prolonged  exposure to a low concentration of ethanol [43].<\/p>\n<h2>Is Alcohol Abuse Hereditary? Why Alcoholism May be Inherited<\/h2>\n<div style='text-align:center'><iframe width='568' height='310' src='https:\/\/www.youtube.com\/embed\/ullz70N3DMY' frameborder='0' alt='is alcoholism a hereditary disease' allowfullscreen><\/iframe><\/div>\n<p>When a person drinks alcohol, several of the brain\u2019s neurotransmitters, or chemical messengers that help to regulate mood and central nervous system functions, are affected. Addiction is also classified as a behavioral disease with social implications. As a complex disease, alcoholism has many potential contributing factors, <a href=\"https:\/\/ecosoberhouse.com\/article\/genetics-of-alcoholism-is-alcohol-abuse-hereditary\/\">is alcoholism a hereditary disease<\/a> including genetics. NIAAA reports that around half of the risk of alcoholism can be linked to genetics, meaning that the disease is considered to be at least partially hereditary and can run in families. This does not mean that just because you have a parent or sibling who struggles with alcoholism, you will, too.<\/p>\n<h2>Genetic link between Alzheimer\u2019s and coronary artery disease<\/h2>\n<p>Levey, D., Le-Niculescu, H., Frank, J., et al. \u201cGenetic risk prediction and neurobiologi[\u2026]anding of alcoholism.\u201d Translational Psychiatry, 2014. The Diagnostic and Statistical Manual of Mental Disorders, 5th edition, text revision (DSM-5-TR), a clinical diagnostic guidebook, indicates that AUD often runs in families at a rate of 3\u20134 times higher compared with the general population. An earlier study from Mexico reported that mothers exposed to a similar chemical called mono-2-ethylhexyl phthalate also had male babies with abnormally smaller penises. Environmental toxins like pesticides, pollutants, and industrial chemicals can also disrupt the endocrine (hormonal) system, including the production of testosterone. The penis will grow proportionately from mini-puberty onward but then experience a sudden growth spurt during puberty, typically around age 12. At this age, the hypothalamus and pituitary gland in the brain release a hormone called luteinizing hormone (LH) that stimulates the production of testosterone from the testicles.<\/p>\n<p><img decoding=\"async\" class='aligncenter' style='display: block;margin-left:auto;margin-right:auto;' src=\"https:\/\/ecosoberhouse.com\/wp-content\/uploads\/72aa5069-affa-4446-be22-190d65ed1a89-1-300x208.webp\" width=\"308px\" alt=\"is alcoholism a hereditary disease\"\/><\/p>\n<h2>Alcohol Addiction And Genetics<\/h2>\n<ul>\n<li>Unhealthy alcohol use includes any alcohol use that puts your health or safety at risk or causes other alcohol-related problems.<\/li>\n<li>There are also countless environmental factors (work, stress, relationships) that may lead to alcoholism.<\/li>\n<li>As it relates to alcoholism, genes, environment and social interaction can all affect a person\u2019s risk level for alcohol addiction.<\/li>\n<li>\u201cGenetic polymorphism in ethanol metaboli[\u2026]abuse and alcoholism.\u201d Molecular Psychiatry, May 26, 2004.<\/li>\n<\/ul>\n<p>Behavioral treatments\u2014also known as alcohol counseling, or talk therapy, and provided by licensed therapists\u2014are aimed at changing drinking behavior. Examples of behavioral treatments are brief interventions and reinforcement approaches, treatments that build motivation and teach skills for coping and preventing a return to drinking, and mindfulness-based therapies. There has been limited knowledge of the molecular genetic underpinnings of addiction until now. Further, most clinical trials and behavioral studies have focused on individual substances, rather than addiction more broadly.<\/p>\n<h2>Share this article<\/h2>\n<p><img decoding=\"async\" class='aligncenter' style='display: block;margin-left:auto;margin-right:auto;' src=\"https:\/\/ecosoberhouse.com\/wp-content\/uploads\/alcohol-powerless-understanding-2-300x200.webp\" width=\"304px\" alt=\"is alcoholism a hereditary disease\"\/><\/p>\n<p><img decoding=\"async\" class='aligncenter' style='display: block;margin-left:auto;margin-right:auto;' src=\"https:\/\/ecosoberhouse.com\/wp-content\/uploads\/image-1-300x170.webp\" width=\"302px\" alt=\"is alcoholism a hereditary disease\"\/><\/p>\n<h2>From model organisms to human genetics<\/h2>\n","protected":false},"excerpt":{"rendered":"<p>Genetics plays a significant role in the size of the penis, but it is not the only factor. Nutritional deficiencies and environmental toxins can impact the development of the penis inside and outside of the womb. Variations in the production of testosterone can also affect the development of the penis during puberty. \u201cGiven the significant [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","om_disable_all_campaigns":false,"footnotes":""},"categories":[177],"tags":[],"class_list":["post-311822","post","type-post","status-publish","format-standard","hentry","category-sober-living"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/ppgsc.uea.edu.br\/index.php\/wp-json\/wp\/v2\/posts\/311822","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ppgsc.uea.edu.br\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ppgsc.uea.edu.br\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ppgsc.uea.edu.br\/index.php\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/ppgsc.uea.edu.br\/index.php\/wp-json\/wp\/v2\/comments?post=311822"}],"version-history":[{"count":1,"href":"https:\/\/ppgsc.uea.edu.br\/index.php\/wp-json\/wp\/v2\/posts\/311822\/revisions"}],"predecessor-version":[{"id":311824,"href":"https:\/\/ppgsc.uea.edu.br\/index.php\/wp-json\/wp\/v2\/posts\/311822\/revisions\/311824"}],"wp:attachment":[{"href":"https:\/\/ppgsc.uea.edu.br\/index.php\/wp-json\/wp\/v2\/media?parent=311822"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ppgsc.uea.edu.br\/index.php\/wp-json\/wp\/v2\/categories?post=311822"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ppgsc.uea.edu.br\/index.php\/wp-json\/wp\/v2\/tags?post=311822"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}